TY - JOUR
T1 - Tenofovir disoproxil fumarate as pre-exposure prophylaxis for HIV prevention in women with osteoporosis
T2 - A case report and review of the literature
AU - Patel, Rupa R.
AU - Presti, Rachel
AU - Harrison, Laura C.
AU - Powderly, William G.
AU - Chan, Philip A.
N1 - Funding Information:
RRP is supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448, sub-award KL2TR000450, from the National Center for Advancing Translational Sciences of the National Institutes of Health; and the National Institute of Mental Health (5R25MH083620-03). PAC is supported by the National Institute of Allergy and Infectious Diseases (1K23AI096923) and the National Institute of Mental Health 1R34MH109371.
Publisher Copyright:
©2018 International Medical Press
PY - 2018
Y1 - 2018
N2 - Pre-exposure prophylaxis (PrEP), using tenofovir disoproxil fumarate (TDF), can effectively prevent HIV acquisition. However, TDF can cause changes in bone mineral density (BMD). There is little information on the use of PrEP among patients with bone disease. We present a case report of a female with pre-existing osteoporosis who was prescribed PrEP. Over the course of 9 months of consistent PrEP use, verified by dried blood spot testing, we report a lack of BMD changes on serial dual-emission X-ray absorptiometry scans in this patient. This case can inform PrEP care for patients with pre-existing bone disease.
AB - Pre-exposure prophylaxis (PrEP), using tenofovir disoproxil fumarate (TDF), can effectively prevent HIV acquisition. However, TDF can cause changes in bone mineral density (BMD). There is little information on the use of PrEP among patients with bone disease. We present a case report of a female with pre-existing osteoporosis who was prescribed PrEP. Over the course of 9 months of consistent PrEP use, verified by dried blood spot testing, we report a lack of BMD changes on serial dual-emission X-ray absorptiometry scans in this patient. This case can inform PrEP care for patients with pre-existing bone disease.
UR - http://www.scopus.com/inward/record.url?scp=85054377144&partnerID=8YFLogxK
U2 - 10.3851/IMP3208
DO - 10.3851/IMP3208
M3 - Article
C2 - 29168695
AN - SCOPUS:85054377144
VL - 23
SP - 379
EP - 382
JO - Antiviral Therapy
JF - Antiviral Therapy
SN - 1359-6535
IS - 4
ER -