TY - JOUR
T1 - Tenecteplase for the Treatment of Pediatric Arterial Ischemic Stroke
T2 - A Safety Surveillance Report
AU - as the International Pediatric Stroke Study and the Pediatric Neurocritical Care Research Group
AU - Sun, Lisa R.
AU - Lee, Sarah
AU - Lee-Eng, Jacqueline
AU - Barry, Megan
AU - Galardi, Maria M.
AU - Harrar, Dana
AU - Hassanein, Sahar M.
AU - Rivkin, Michael J.
AU - Torres, Marcela
AU - Wilson, Jenny L.
AU - Amlie-Lefond, Catherine
AU - Guilliams, Kristin
PY - 2025/2/11
Y1 - 2025/2/11
N2 - OBJECTIVES: Intravenous tenecteplase (TNK) is increasingly used to treat adult patients with acute arterial ischemic stroke, but the risk profile of TNK in childhood stroke is unknown. This study aims to prospectively gather safety data regarding TNK administration in children. METHODS: Since December 2023, a monthly email survey was sent to participants recruited from the International Pediatric Stroke Study and Pediatric Neurocritical Care Research Group querying recent experience with TNK in childhood stroke. Limited demographic, safety, and outcome data were collected in a secure REDCap database. Detailed clinical data were not collected. RESULTS: Eleven children were reported to have received TNK between February 2023 and January 2024. Ten were adolescents (13-17 years old), and 1 was between 5 and 12 years old. TNK was given at an outside facility before transfer to the reporting facility in 7 cases. Final diagnosis was stroke in 8 cases and stroke mimic in 3 cases. No major safety concerns or TNK-related intracranial hemorrhages on follow-up imaging were reported. DISCUSSION: Our initial data suggest that TNK may be safe in childhood arterial ischemic stroke. Strategically designed prospective studies are needed to further define safety, optimal dosage, and efficacy of TNK in acute pediatric stroke.
AB - OBJECTIVES: Intravenous tenecteplase (TNK) is increasingly used to treat adult patients with acute arterial ischemic stroke, but the risk profile of TNK in childhood stroke is unknown. This study aims to prospectively gather safety data regarding TNK administration in children. METHODS: Since December 2023, a monthly email survey was sent to participants recruited from the International Pediatric Stroke Study and Pediatric Neurocritical Care Research Group querying recent experience with TNK in childhood stroke. Limited demographic, safety, and outcome data were collected in a secure REDCap database. Detailed clinical data were not collected. RESULTS: Eleven children were reported to have received TNK between February 2023 and January 2024. Ten were adolescents (13-17 years old), and 1 was between 5 and 12 years old. TNK was given at an outside facility before transfer to the reporting facility in 7 cases. Final diagnosis was stroke in 8 cases and stroke mimic in 3 cases. No major safety concerns or TNK-related intracranial hemorrhages on follow-up imaging were reported. DISCUSSION: Our initial data suggest that TNK may be safe in childhood arterial ischemic stroke. Strategically designed prospective studies are needed to further define safety, optimal dosage, and efficacy of TNK in acute pediatric stroke.
UR - http://www.scopus.com/inward/record.url?scp=85215596456&partnerID=8YFLogxK
U2 - 10.1212/WNL.0000000000210310
DO - 10.1212/WNL.0000000000210310
M3 - Article
C2 - 39805054
AN - SCOPUS:85215596456
SN - 0028-3878
VL - 104
SP - e210310
JO - Neurology
JF - Neurology
IS - 3
ER -