Ten-Year Oncologic Outcomes Following Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium

Ahmed A. Hussein, Ahmed S. Elsayed, Naif A. Aldhaam, Zhe Jing, Jennifer Osei, Jihad Kaouk, Juan Palou Redorta, Mani Menon, James Peabody, Prokar Dasgupta, Mohammed Shamim Khan, Alexandre Mottrie, Michael Stöckle, Ashok Hemal, Lee Richstone, Abolfazl Hosseini, Peter Wiklund, Francis Schanne, Eric Kim, Koon Ho RhaKhurshid A. Guru

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Abstract

PURPOSE: Radical cystectomy is the gold standard for nonmetastatic muscle invasive bladder cancer and for refractory nonmuscle invasive disease. Compared to open radical cystectomy, robot-assisted radical cystectomy has been shown to provide comparable early oncologic outcomes and improved perioperative outcomes. However, there is a paucity of data on long-term oncologic outcomes and concerns about a higher incidence of local recurrence after robot-assisted radical cystectomy. We report 10-year oncologic outcomes following robot-assisted radical cystectomy using a multinational database. MATERIALS AND METHODS: We retrospectively reviewed the prospective International Robotic Cystectomy Consortium database. Consecutive patients who underwent robot-assisted radical cystectomy 10 years ago or earlier were included in analysis. Data were reviewed for demographics, and perioperative, pathological and oncologic outcomes. Kaplan-Meier curves were used to depict recurrence-free, disease specific and overall survival. Multivariate stepwise Cox regression models were applied to identify variables associated with recurrence-free, disease specific and overall survival. RESULTS: We identified 446 patients with a median age of 67 years (IQR 59-76). Of the patients 10% received neoadjuvant chemotherapy, 51% experienced any complication, 23% had high grade complications and 4% died within 3 months of robot-assisted radical cystectomy. Disease was pT3 or greater in 43% of patients and pN+ in 24% while a positive soft tissue surgical margin was observed in 7%. At a median followup of 5 years (IQR 2-10, maximum 14) local and distant recurrence had developed in 15% and 29% of patients, respectively. Ten-year recurrence-free, disease specific and overall survival rates were 59%, 65% and 35%, respectively. Patients with pT3 or greater and pN+ disease showed worse recurrence-free, disease specific and overall survival. CONCLUSIONS: Long-term oncologic outcomes, and recurrence rates and patterns after robot-assisted radical cystectomy seem comparable to those in open series. Advanced disease stage and positive surgical margins remain the main determinants of survival after radical cystectomy.

Original languageEnglish
Pages (from-to)927-935
Number of pages9
JournalThe Journal of urology
Volume202
Issue number5
DOIs
StatePublished - Nov 1 2019

Keywords

  • cystectomy
  • mortality
  • recurrence
  • robotic surgical procedures
  • urinary bladder neoplasms

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    Hussein, A. A., Elsayed, A. S., Aldhaam, N. A., Jing, Z., Osei, J., Kaouk, J., Redorta, J. P., Menon, M., Peabody, J., Dasgupta, P., Khan, M. S., Mottrie, A., Stöckle, M., Hemal, A., Richstone, L., Hosseini, A., Wiklund, P., Schanne, F., Kim, E., ... Guru, K. A. (2019). Ten-Year Oncologic Outcomes Following Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium. The Journal of urology, 202(5), 927-935. https://doi.org/10.1097/JU.0000000000000386