Temporal relationship between antitumor necrosis factor-α antibody therapy and recrudescence of head and neck squamous cell carcinoma

Samuel H. Engel, Timothy E. Hullar, Douglas R. Adkins, Wade L. Thorstad, John B. Sunwoo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Tumor necrosis factor (TNF)-α inhibitors have been used effectively to treat rheumatoid arthritis and inflammatory bowel disease. Although the role of TNF-α in tumor development is not well understood, an increased risk of malignancies with anti-TNF-α therapy has been suggested. We report an instructive case of a patient, treated for Crohn's disease with infliximab, who presented with a neck abscess diagnosed to be head and neck squamous cell carcinoma. The patient's clinical course illustrates a temporal relationship between reappearance of his cancer after a complete response to therapy and the resumption of infliximab for worsening Crohn's disease.

Original languageEnglish
Pages (from-to)450-452
Number of pages3
JournalLaryngoscope
Volume118
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Abscess
  • Head and neck cancer
  • Immune
  • Immune system
  • Infliximab
  • Malignancy
  • Remicade
  • Squamous cell carcinoma
  • TNF-α inhibitors
  • Tumor necrosis factor-α

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