TY - JOUR
T1 - Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
AU - Ances, Beau M.
AU - Buerk, Donald G.
AU - Greenberg, Joel H.
AU - Detre, John A.
PY - 2001/6/22
Y1 - 2001/6/22
N2 - The partial pressure of tissue oxygen (pO2) was measured in rat somatosensory cortex during periodic electrical forepaw stimulation of either 1 min or 4 s in duration, and correlated with simultaneous laser Doppler flowmetry. For both stimulus durations, a transient decrease in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. With protracted stimulation, tissue pO2 remained only slightly above pre-stimulus baseline, while blood flow was maintained at a reduced plateau phase. A sustained post-stimulus undershoot in tissue pO2 was observed only for the 1 min stimulus. These findings suggest a complex dynamic relationship between oxygen utilization and blood flow.
AB - The partial pressure of tissue oxygen (pO2) was measured in rat somatosensory cortex during periodic electrical forepaw stimulation of either 1 min or 4 s in duration, and correlated with simultaneous laser Doppler flowmetry. For both stimulus durations, a transient decrease in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. With protracted stimulation, tissue pO2 remained only slightly above pre-stimulus baseline, while blood flow was maintained at a reduced plateau phase. A sustained post-stimulus undershoot in tissue pO2 was observed only for the 1 min stimulus. These findings suggest a complex dynamic relationship between oxygen utilization and blood flow.
KW - Cerebral blood flow
KW - Laser Doppler flowmetry
KW - Tissue oxygen electrode
UR - http://www.scopus.com/inward/record.url?scp=0035933660&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)01868-7
DO - 10.1016/S0304-3940(01)01868-7
M3 - Article
C2 - 11403969
AN - SCOPUS:0035933660
SN - 0304-3940
VL - 306
SP - 106
EP - 110
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -