Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats

Beau M. Ances, Donald G. Buerk, Joel H. Greenberg, John A. Detre

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

The partial pressure of tissue oxygen (pO2) was measured in rat somatosensory cortex during periodic electrical forepaw stimulation of either 1 min or 4 s in duration, and correlated with simultaneous laser Doppler flowmetry. For both stimulus durations, a transient decrease in tissue pO2 preceded blood flow changes, followed by a peak in blood flow and an overshoot in tissue pO2. With protracted stimulation, tissue pO2 remained only slightly above pre-stimulus baseline, while blood flow was maintained at a reduced plateau phase. A sustained post-stimulus undershoot in tissue pO2 was observed only for the 1 min stimulus. These findings suggest a complex dynamic relationship between oxygen utilization and blood flow.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalNeuroscience Letters
Volume306
Issue number1-2
DOIs
StatePublished - Jun 22 2001
Externally publishedYes

Keywords

  • Cerebral blood flow
  • Laser Doppler flowmetry
  • Tissue oxygen electrode

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