TY - JOUR
T1 - Template images for nonhuman primate neuroimaging
T2 - 2. Macaque
AU - Black, Kevin J.
AU - Koller, Jonathan M.
AU - Snyder, Abraham Z.
AU - Perlmutter, Joel S.
N1 - Funding Information:
We thank Terry Anderson, Ryan Collins, and Bettina Tobben for technical assistance and Drs. Tamara Hershey and Jonathan Mink for some of the images used. Supported by NIH Grants NS01898 and NS31001, the Tourette Syndrome Association, the Greater St. Louis chapter of the American Parkinson Disease Association, the Mary and Robert Bronstein Foundation, the McDonnell Center for the Study of Higher Brain Function, and a Young Investigator Award to K.J.B. from NARSAD (the National Alliance for Research on Schizophrenia and Depression).
PY - 2001
Y1 - 2001
N2 - Neuroimaging studies are increasingly performed in macaque species, including the pig-tailed macaque (Macaca nemestrina). At times experimental questions can be answered by analysis of functional images in individual subjects and reference to a structural image in that subject. However, coregistration of functional brain images across many subjects offers the experimental advantage of enabling voxel-based analysis over multiple subjects and is therefore widely used in human studies. Voxel-based coregistration methods require a high-quality 3D template image. We created such templates, derived from T1-weighted MRI and blood-flow PET images from 12 nemestrina monkeys. We designed the macaque templates to be maximally compatible with the baboon template images described in a companion paper, to facilitate cross-species comparison of functional imaging data. Here we present data showing the reliability and validity of automatic image registration to the template. Alignment of selected internal fiducial points was accurate to within 1.9 mm overall (mean) even across species. The template images, along with copies aligned to the UCLA nemestrina brain atlas, are able on the Internet (purl.org/net/kbmd/n2k) and can be used as targets with any image registration software.
AB - Neuroimaging studies are increasingly performed in macaque species, including the pig-tailed macaque (Macaca nemestrina). At times experimental questions can be answered by analysis of functional images in individual subjects and reference to a structural image in that subject. However, coregistration of functional brain images across many subjects offers the experimental advantage of enabling voxel-based analysis over multiple subjects and is therefore widely used in human studies. Voxel-based coregistration methods require a high-quality 3D template image. We created such templates, derived from T1-weighted MRI and blood-flow PET images from 12 nemestrina monkeys. We designed the macaque templates to be maximally compatible with the baboon template images described in a companion paper, to facilitate cross-species comparison of functional imaging data. Here we present data showing the reliability and validity of automatic image registration to the template. Alignment of selected internal fiducial points was accurate to within 1.9 mm overall (mean) even across species. The template images, along with copies aligned to the UCLA nemestrina brain atlas, are able on the Internet (purl.org/net/kbmd/n2k) and can be used as targets with any image registration software.
UR - http://www.scopus.com/inward/record.url?scp=0034867626&partnerID=8YFLogxK
U2 - 10.1006/nimg.2001.0871
DO - 10.1006/nimg.2001.0871
M3 - Article
C2 - 11506546
AN - SCOPUS:0034867626
SN - 1053-8119
VL - 14
SP - 744
EP - 748
JO - NeuroImage
JF - NeuroImage
IS - 3
ER -