TY - JOUR
T1 - Template images for nonhuman primate neuroimaging
T2 - 1. Baboon
AU - Black, Kevin J.
AU - Snyder, Abraham Z.
AU - Koller, Jonathan M.
AU - Gado, Mokhtar H.
AU - Perlmutter, Joel S.
N1 - Funding Information:
We thank Terry Anderson, Ryan Collins, and Bettina Tobben for technical assistance, and Drs. Tamara Hershey and Thomas Conturo for some of the images used. Supported by NIH Grants NS01898 and NS31001, the Tourette Syndrome Association, the Greater St. Louis chapter of the American Parkinson Disease Association, the Mary and Robert Bronstein foundation, the McDonnell Center for the Study of Higher Brain Function, and a Young Investigator award to K.J.B. from NARSAD (the National Alliance for Research on Schizophrenia and Depression). This work was supported with funding from NIMH grant 1 R03 MH63627-01 and the Essel Foundation.
PY - 2001
Y1 - 2001
N2 - Coregistration of functional brain images across many subjects offers several experimental advantages and is widely used for studies in humans. Voxel-based coregistration methods require a high-quality 3-D template image, preferably one that corresponds to a published atlas. Template images are available for human, but we could not find an appropriate template for neuroimaging studies in baboon. Here we describe the formation of a T1-weighted structural MR template image and a PET blood flow template, derived from 9 and 7 baboons, respectively. Custom software aligns individual MR images to the MRI template; human supervision is needed only to initially estimate any gross rotational misalignment. In these aligned individual images, internal subcortical fiducial points correspond closely to a photomicrographic baboon atlas with an average error of 1.53 mm. Cortical test points showed a mean error of 1.99 mm compared to the mean location for each point. Alignment of individual PET blood flow images directly to the PET template was compared to a two-step alignment process via each subject's MR image. The two transformations were identical within 0.41 mm, 0.54°, and 1.0% (translation, rotation, and linear stretch; mean). These quantities provide a check on the validity of the alignment software as well as of the template images. The baboon structural MR and blood flow PET templates are available on the Internet (purl.org/net/kbmd/b2k) and can be used as targets for any image registration software.
AB - Coregistration of functional brain images across many subjects offers several experimental advantages and is widely used for studies in humans. Voxel-based coregistration methods require a high-quality 3-D template image, preferably one that corresponds to a published atlas. Template images are available for human, but we could not find an appropriate template for neuroimaging studies in baboon. Here we describe the formation of a T1-weighted structural MR template image and a PET blood flow template, derived from 9 and 7 baboons, respectively. Custom software aligns individual MR images to the MRI template; human supervision is needed only to initially estimate any gross rotational misalignment. In these aligned individual images, internal subcortical fiducial points correspond closely to a photomicrographic baboon atlas with an average error of 1.53 mm. Cortical test points showed a mean error of 1.99 mm compared to the mean location for each point. Alignment of individual PET blood flow images directly to the PET template was compared to a two-step alignment process via each subject's MR image. The two transformations were identical within 0.41 mm, 0.54°, and 1.0% (translation, rotation, and linear stretch; mean). These quantities provide a check on the validity of the alignment software as well as of the template images. The baboon structural MR and blood flow PET templates are available on the Internet (purl.org/net/kbmd/b2k) and can be used as targets for any image registration software.
UR - https://www.scopus.com/pages/publications/0034869592
U2 - 10.1006/nimg.2001.0752
DO - 10.1006/nimg.2001.0752
M3 - Article
C2 - 11506545
AN - SCOPUS:0034869592
SN - 1053-8119
VL - 14
SP - 736
EP - 743
JO - NeuroImage
JF - NeuroImage
IS - 3
ER -