TY - JOUR
T1 - Temperature-sensitive variants of Histoplasma capsulatum isolated from patients with acquired immunodeficiency syndrome
AU - Spitzer, Eric D.
AU - Keath, Elizabeth J.
AU - Travis, Sharon J.
AU - Painter, Audrey A.
AU - Kobayashi, George S.
AU - Medoff, Gerald
PY - 1990/7
Y1 - 1990/7
N2 - Histoplasma capsulatum isolates from three St. Louis area AIDS patients with disseminated histoplasmosis were found to be closely related to the temperature-sensitive, previously unique, Downs strain based on growth phenotype and restriction fragment length polymorphisms (RFLP) involving mitochondrial DNA, ribosomal DNA, and the yps-3 gene. H. capsulatum isolates from five non-AIDS patients in the St. Louis area with disseminated histoplasmosis or chronic pulmonary histoplasmosis had the growth phenotype and RFLP pattern characteristic of most strains isolated from other regions of the USA.
AB - Histoplasma capsulatum isolates from three St. Louis area AIDS patients with disseminated histoplasmosis were found to be closely related to the temperature-sensitive, previously unique, Downs strain based on growth phenotype and restriction fragment length polymorphisms (RFLP) involving mitochondrial DNA, ribosomal DNA, and the yps-3 gene. H. capsulatum isolates from five non-AIDS patients in the St. Louis area with disseminated histoplasmosis or chronic pulmonary histoplasmosis had the growth phenotype and RFLP pattern characteristic of most strains isolated from other regions of the USA.
UR - http://www.scopus.com/inward/record.url?scp=0025340865&partnerID=8YFLogxK
U2 - 10.1093/infdis/162.1.258
DO - 10.1093/infdis/162.1.258
M3 - Article
C2 - 1972383
AN - SCOPUS:0025340865
SN - 0022-1899
VL - 162
SP - 258
EP - 261
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -