Temperature-sensitive variants of Histoplasma capsulatum isolated from patients with acquired immunodeficiency syndrome

Eric D. Spitzer, Elizabeth J. Keath, Sharon J. Travis, Audrey A. Painter, George S. Kobayashi, Gerald Medoff

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Histoplasma capsulatum isolates from three St. Louis area AIDS patients with disseminated histoplasmosis were found to be closely related to the temperature-sensitive, previously unique, Downs strain based on growth phenotype and restriction fragment length polymorphisms (RFLP) involving mitochondrial DNA, ribosomal DNA, and the yps-3 gene. H. capsulatum isolates from five non-AIDS patients in the St. Louis area with disseminated histoplasmosis or chronic pulmonary histoplasmosis had the growth phenotype and RFLP pattern characteristic of most strains isolated from other regions of the USA.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalJournal of Infectious Diseases
Volume162
Issue number1
DOIs
StatePublished - Jul 1990

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