TY - JOUR
T1 - Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery
AU - He, Shawn
AU - Tourkakis, George
AU - Berezin, Oleg
AU - Gerasimchuk, Nikolay
AU - Zhang, Hairong
AU - Zhou, Haiying
AU - Izraely, Asaf
AU - Akers, Walter J.
AU - Berezin, Mikhail Y.
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2016.
PY - 2016/4/14
Y1 - 2016/4/14
N2 - Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.
AB - Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.
UR - http://www.scopus.com/inward/record.url?scp=84963831255&partnerID=8YFLogxK
U2 - 10.1039/c6tc00122j
DO - 10.1039/c6tc00122j
M3 - Article
AN - SCOPUS:84963831255
SN - 2050-7534
VL - 4
SP - 3028
EP - 3035
JO - Journal of Materials Chemistry C
JF - Journal of Materials Chemistry C
IS - 14
ER -