Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Shawn He, George Tourkakis, Oleg Berezin, Nikolay Gerasimchuk, Hairong Zhang, Haiying Zhou, Asaf Izraely, Walter J. Akers, Mikhail Y. Berezin

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

Original languageEnglish
Pages (from-to)3028-3035
Number of pages8
JournalJournal of Materials Chemistry C
Volume4
Issue number14
DOIs
StatePublished - Apr 14 2016

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    He, S., Tourkakis, G., Berezin, O., Gerasimchuk, N., Zhang, H., Zhou, H., Izraely, A., Akers, W. J., & Berezin, M. Y. (2016). Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery. Journal of Materials Chemistry C, 4(14), 3028-3035. https://doi.org/10.1039/c6tc00122j