Temperament predicts clomipramine and desipramine response in major depression

Peter R. Joyce, Roger T. Mulder, C. Robert Cloninger

    Research output: Contribution to journalArticlepeer-review

    189 Scopus citations


    Clinical predictors of drug response in major depression have been weak and inconsistent. Eighty-four patients suffering from a current major depressive episode completed a 6-week double-blind trial of either clomipramine or desipramine. Temperament, as measured by the Tridimensional Personality Questionnaire, accounted for 35% of the variance in treatment outcome, compared with less than 5% predicted by clinical variables. In the more severely depressed patients, temperament predicted nearly 50% of the variance in treatment outcome, which is the first time that such a substantial predictor of drug response has been identified. Within depressed women, temperament also predicted response to different antidepressant drugs. The potential importance of temperament, and the need for replication of these findings is discussed.

    Original languageEnglish
    Pages (from-to)35-46
    Number of pages12
    JournalJournal of affective disorders
    Issue number1
    StatePublished - Jan 1994


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