Telomeres are nucleoprotein structures found at the termini of linear eukaryotic chromosomes. They serve as a buffer against the end replication problem and protect chromosome ends from inappropriate DNA repair; thus, telomeres are essential for the maintenance of genome stability and continued cellular proliferation. With each cell division, telomeres shorten in the absence of telomerase. Once telomeres become critically short, they trigger the onset of cellular senescence. Cancer cells must bypass this event by inappropriately elongating or stabilizing their telomeres.

Original languageEnglish
Title of host publicationMolecular Cell Biology
PublisherElsevier Inc.
Number of pages9
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
StatePublished - Jan 1 2016


  • ALT
  • Cancer
  • Chromosome
  • DNA
  • Dyskeratosis congenita
  • G-quadruplex
  • Recombination
  • Replication
  • Resection
  • Senescence
  • Shelterin
  • T-Loop
  • Telomerase
  • Telomere


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