Telomere Biology

D. C. Teasley; S. A. Stewart

doi:10.1016/B978-0-12-394447-4.10043-4

Telomere Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Telomeres are nucleoprotein structures found at the termini of linear eukaryotic chromosomes. They serve as a buffer against the end replication problem and protect chromosome ends from inappropriate DNA repair; thus, telomeres are essential for the maintenance of genome stability and continued cellular proliferation. With each cell division, telomeres shorten in the absence of telomerase. Once telomeres become critically short, they trigger the onset of cellular senescence. Cancer cells must bypass this event by inappropriately elongating or stabilizing their telomeres.

Original language	English
Title of host publication	Molecular Cell Biology
Publisher	Elsevier Inc.
Pages	426-434
Number of pages	9
Volume	1
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.10043-4
State	Published - Jan 1 2016

Keywords

ALT
Cancer
Chromosome
DNA
Dyskeratosis congenita
G-quadruplex
Recombination
Replication
Resection
Senescence
Shelterin
T-Loop
Telomerase
Telomere

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10.1016/B978-0-12-394447-4.10043-4

Cite this

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title = "Telomere Biology",

abstract = "Telomeres are nucleoprotein structures found at the termini of linear eukaryotic chromosomes. They serve as a buffer against the end replication problem and protect chromosome ends from inappropriate DNA repair; thus, telomeres are essential for the maintenance of genome stability and continued cellular proliferation. With each cell division, telomeres shorten in the absence of telomerase. Once telomeres become critically short, they trigger the onset of cellular senescence. Cancer cells must bypass this event by inappropriately elongating or stabilizing their telomeres.",

keywords = "ALT, Cancer, Chromosome, DNA, Dyskeratosis congenita, G-quadruplex, Recombination, Replication, Resection, Senescence, Shelterin, T-Loop, Telomerase, Telomere",

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doi = "10.1016/B978-0-12-394447-4.10043-4",

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T1 - Telomere Biology

AU - Teasley, D. C.

AU - Stewart, S. A.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Telomeres are nucleoprotein structures found at the termini of linear eukaryotic chromosomes. They serve as a buffer against the end replication problem and protect chromosome ends from inappropriate DNA repair; thus, telomeres are essential for the maintenance of genome stability and continued cellular proliferation. With each cell division, telomeres shorten in the absence of telomerase. Once telomeres become critically short, they trigger the onset of cellular senescence. Cancer cells must bypass this event by inappropriately elongating or stabilizing their telomeres.

AB - Telomeres are nucleoprotein structures found at the termini of linear eukaryotic chromosomes. They serve as a buffer against the end replication problem and protect chromosome ends from inappropriate DNA repair; thus, telomeres are essential for the maintenance of genome stability and continued cellular proliferation. With each cell division, telomeres shorten in the absence of telomerase. Once telomeres become critically short, they trigger the onset of cellular senescence. Cancer cells must bypass this event by inappropriately elongating or stabilizing their telomeres.

KW - ALT

KW - Cancer

KW - Chromosome

KW - DNA

KW - Dyskeratosis congenita

KW - G-quadruplex

KW - Recombination

KW - Replication

KW - Resection

KW - Senescence

KW - Shelterin

KW - T-Loop

KW - Telomerase

KW - Telomere

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U2 - 10.1016/B978-0-12-394447-4.10043-4

DO - 10.1016/B978-0-12-394447-4.10043-4

M3 - Chapter

AN - SCOPUS:85042773389

SN - 9780123947963

VL - 1

SP - 426

EP - 434

BT - Molecular Cell Biology

PB - Elsevier Inc.

ER -

Telomere Biology

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Keywords

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