Television watching and risk of colorectal adenoma

Y. Cao, N. N. Keum, A. T. Chan, C. S. Fuchs, K. Wu, E. L. Giovannucci

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Prolonged TV watching, a major sedentary behaviour, is associated with increased risk of obesity and diabetes and may involve in colorectal carcinogenesis.Methods:We conducted a cross-sectional analysis among 31 065 men with ≥1 endoscopy in the Health Professionals Follow-up Study (1988-2008) to evaluate sitting while watching TV and its joint influence with leisure-time physical activity on risk of colorectal adenoma. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).Results:Prolonged sitting while watching TV was significantly associated with increased risk of colorectal adenoma (n=4280), and adjusting for physical activity or a potential mediator body mass index did not change the estimates. The ORs (95% CIs) across categories of TV watching (0-6, 7-13, 14-20, and 21+ h per week) were 1.00 (referent), 1.09 (1.01-1.17), 1.16 (1.06-1.27), and 1.10 (0.97-1.25) (OR per 14-h per week increment=1.11; 95% CI: 1.04-1.18; P trend =0.001). Compared with the least sedentary (0-6 h per week of TV) and most physically active (highest quintile) men, the most sedentary (14+ h per week) and least active (lowest quintile) men had a significant increased risk of adenoma (OR=1.25; 95% CI: 1.05-1.49), particularly for high-risk adenoma.Conclusions:Prolonged TV viewing is associated with modest increased risk of colorectal adenoma independent of leisure-time physical activity and minimally mediated by obesity.

Original languageEnglish
Pages (from-to)934-942
Number of pages9
JournalBritish Journal of Cancer
Volume112
Issue number5
DOIs
StatePublished - Mar 3 2015
Externally publishedYes

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    Cao, Y., Keum, N. N., Chan, A. T., Fuchs, C. S., Wu, K., & Giovannucci, E. L. (2015). Television watching and risk of colorectal adenoma. British Journal of Cancer, 112(5), 934-942. https://doi.org/10.1038/bjc.2014.655