Technology insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis?

Ellen M. Mowry, John H. Woo, Beau M. Ances

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Baló's concentric sclerosis (BCS) has long been considered to be a variant of multiple sclerosis. Although BCS was initially described over 100 years ago, relatively few antemortem cases have been identified, and the exact pathogenesis remains unknown. Inflammatory protective ischemic preconditioning has recently been suggested as a mechanism by which the typical concentric rings of the BCS lesion are formed. Advanced neuroimaging can provide important in vivo markers of disease progression that can assist in the diagnosis and management of patients with BCS. In this Review, we discuss evidence from longitudinal neuroimaging studies that supports the role of ischemic preconditioning in BCS.

Original languageEnglish
Pages (from-to)341-348
Number of pages8
JournalNature Clinical Practice Neurology
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2007
Externally publishedYes

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