Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates

Gerard Aguilar Pérez; Rohit V. Pappu; Dragomir Milovanovic

doi:10.1016/j.tcb.2024.02.007

Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates

Gerard Aguilar Pérez, Rohit V. Pappu, Dragomir Milovanovic

Research output: Contribution to journal › Short survey › peer-review

Abstract

Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study, Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in postsynaptic densities modulates the apparent miscibility of underlying components, thus enabling intracondensate demixing-to-mixing transitions.

Original language	English
Pages (from-to)	274-276
Number of pages	3
Journal	Trends in Cell Biology
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.tcb.2024.02.007
State	Published - Apr 2024

Keywords

condensates
interface
neuronal transmission
phase separation
phosphorylation
postsynaptic density

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10.1016/j.tcb.2024.02.007

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title = "Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates",

abstract = "Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study, Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in postsynaptic densities modulates the apparent miscibility of underlying components, thus enabling intracondensate demixing-to-mixing transitions.",

keywords = "condensates, interface, neuronal transmission, phase separation, phosphorylation, postsynaptic density",

author = "{Aguilar P{\'e}rez}, Gerard and Pappu, {Rohit V.} and Dragomir Milovanovic",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = apr,

doi = "10.1016/j.tcb.2024.02.007",

language = "English",

volume = "34",

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T2 - phosphorylation regulates the internal interfaces of postsynaptic condensates

AU - Aguilar Pérez, Gerard

AU - Pappu, Rohit V.

AU - Milovanovic, Dragomir

PY - 2024/4

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N2 - Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study, Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in postsynaptic densities modulates the apparent miscibility of underlying components, thus enabling intracondensate demixing-to-mixing transitions.

AB - Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study, Wu et al. show that phosphorylation of a key scaffold protein that drives condensates in postsynaptic densities modulates the apparent miscibility of underlying components, thus enabling intracondensate demixing-to-mixing transitions.

KW - condensates

KW - interface

KW - neuronal transmission

KW - phase separation

KW - phosphorylation

KW - postsynaptic density

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U2 - 10.1016/j.tcb.2024.02.007

DO - 10.1016/j.tcb.2024.02.007

M3 - Short survey

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SN - 0962-8924

VL - 34

SP - 274

EP - 276

JO - Trends in Cell Biology

JF - Trends in Cell Biology

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ER -

Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates

Abstract

Keywords

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