TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

John P. Rice; Rosalind J. Neuman; Stacy L. Hoshaw; E. Warwick Daw; Chi Gu

doi:10.1002/gepi.1370120623

TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

John P. Rice
, Rosalind J. Neuman
, Stacy L. Hoshaw
, E. Warwick Daw
, Chi Gu

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	659-664
Number of pages	6
Journal	Genetic Epidemiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/gepi.1370120623
State	Published - 1995

Keywords

linkage analysis
mod score
transmission/disequilibrium test

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10.1002/gepi.1370120623

Cite this

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title = "TDT with covariates and genomic screens with mod scores: Their behavior on simulated data",

abstract = "We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. {\textcopyright} 1995 Wiley‐Liss, Inc.",

keywords = "linkage analysis, mod score, transmission/disequilibrium test",

author = "Rice, \{John P.\} and Neuman, \{Rosalind J.\} and Hoshaw, \{Stacy L.\} and Daw, \{E. Warwick\} and Chi Gu",

year = "1995",

doi = "10.1002/gepi.1370120623",

language = "English",

volume = "12",

pages = "659--664",

journal = "Genetic Epidemiology",

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T1 - TDT with covariates and genomic screens with mod scores

T2 - Their behavior on simulated data

AU - Rice, John P.

AU - Neuman, Rosalind J.

AU - Hoshaw, Stacy L.

AU - Daw, E. Warwick

AU - Gu, Chi

PY - 1995

Y1 - 1995

N2 - We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

AB - We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

KW - linkage analysis

KW - mod score

KW - transmission/disequilibrium test

UR - https://www.scopus.com/pages/publications/0029609590

U2 - 10.1002/gepi.1370120623

DO - 10.1002/gepi.1370120623

M3 - Article

C2 - 8787990

AN - SCOPUS:0029609590

SN - 0741-0395

VL - 12

SP - 659

EP - 664

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

Abstract

Keywords

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