TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

John P. Rice, Rosalind J. Neuman, Stacy L. Hoshaw, E. Warwick Daw, Chi Gu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)659-664
Number of pages6
JournalGenetic Epidemiology
Volume12
Issue number6
DOIs
StatePublished - 1995

Keywords

  • linkage analysis
  • mod score
  • transmission/disequilibrium test

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