TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

John P. Rice; Rosalind J. Neuman; Stacy L. Hoshaw; E. Warwick Daw; Chi Gu

doi:10.1002/gepi.1370120623

TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

John P. Rice, Rosalind J. Neuman, Stacy L. Hoshaw, E. Warwick Daw, Chi Gu

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	659-664
Number of pages	6
Journal	Genetic Epidemiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1002/gepi.1370120623
State	Published - 1995

Keywords

linkage analysis
mod score
transmission/disequilibrium test

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10.1002/gepi.1370120623

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abstract = "We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. {\textcopyright} 1995 Wiley‐Liss, Inc.",

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author = "Rice, {John P.} and Neuman, {Rosalind J.} and Hoshaw, {Stacy L.} and Daw, {E. Warwick} and Chi Gu",

year = "1995",

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pages = "659--664",

journal = "Genetic Epidemiology",

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AU - Rice, John P.

AU - Neuman, Rosalind J.

AU - Hoshaw, Stacy L.

AU - Daw, E. Warwick

AU - Gu, Chi

PY - 1995

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N2 - We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

AB - We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus. © 1995 Wiley‐Liss, Inc.

KW - linkage analysis

KW - mod score

KW - transmission/disequilibrium test

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DO - 10.1002/gepi.1370120623

M3 - Article

C2 - 8787990

AN - SCOPUS:0029609590

SN - 0741-0395

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SP - 659

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JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

TDT with covariates and genomic screens with mod scores: Their behavior on simulated data

Abstract

Keywords

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