Taxol in advanced, hormone‐refractory carcinoma of the prostate. A phase II trial of the eastern cooperative oncology group

Bruce J. Roth, Patrick J. Loehrer, Beow Yong Yeap, George Wilding, Basil Kasimis, David McLeod

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Background. Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone‐refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. Methods. Twenty‐three patients with hormone‐refractory prostate cancer and bidimensionally measurable disease were treated with Taxol by 24‐hour continuous infusion at 135–170 mg/M2 every 21 days for a maximum of 6 cycles. Results. Eighty‐five courses of Taxol were administered to 23 patients. One patient (4.3%) experienced a partial response lasting 9 months, and four other patients with radiographically stable disease had minor reductions in the serum prostate‐specific antigen (PSA) of 16–24%. Eleven patients (47.8%) had stable disease, and progressive disease developed in 9 patients (39.1%) during therapy. Median survival was 9 months. Leukopenia was the dose‐limiting toxicity with 13% of patients having Grade 3 and 61% having Grade 4 toxicity, and granulocytopenic fever developed in 26%. Three patients experienced sudden cardiovascular events while participating in the study, including one patient with a nonfatal, non‐Q‐wave myocardial infarction that occurred during a taxol infusion, and two patients who had sudden deaths 9 days and 30 days after receiving their last taxol dose, respectively. Conclusions. In the subset of patients with hormonerefractory prostate cancer and bidimensionally measurable disease, Taxol at this dosage has only minor activity.

Original languageEnglish
Pages (from-to)2457-2460
Number of pages4
JournalCancer
Volume72
Issue number8
DOIs
StatePublished - Oct 15 1993
Externally publishedYes

Keywords

  • Taxol
  • hormonerefractory
  • medical oncology
  • prostate cancer

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