Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals

Sarah A. Cooley; Jeremy F. Strain; Helen Beaumont; Anna H. Boerwinkle; John Doyle; John C. Morris; Tammie L. Benzinger; Beau M. Ances

doi:10.1093/infdis/jiy663

Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals

Sarah A. Cooley, Jeremy F. Strain, Helen Beaumont, Anna H. Boerwinkle, John Doyle, John C. Morris, Tammie L. Benzinger, Beau M. Ances

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4⁺ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.

Original language	English
Article number	jiy663
Pages (from-to)	68-72
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	220
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiy663
State	Published - Jun 5 2019

Keywords

Alzheimer's disease
HIV dementia
positron emission tomography

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10.1093/infdis/jiy663

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title = "Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals",

abstract = "Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.",

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AU - Strain, Jeremy F.

AU - Beaumont, Helen

AU - Boerwinkle, Anna H.

AU - Doyle, John

AU - Morris, John C.

AU - Benzinger, Tammie L.

AU - Ances, Beau M.

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AB - Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.

KW - Alzheimer's disease

KW - HIV dementia

KW - positron emission tomography

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Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals

Abstract

Keywords

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