Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals

Sarah A. Cooley, Jeremy F. Strain, Helen Beaumont, Anna H. Boerwinkle, John Doyle, John C. Morris, Tammie L. Benzinger, Beau M. Ances

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Regional standardized uptake value ratios (SUVRs) for tau positron emission tomography (PET) were compared among 19 cognitively normal human immunodeficiency virus (HIV)-negative control individuals, 20 HIV-negative patients with symptomatic Alzheimer disease, 15 cognitively normal HIV-positive individuals, and 17 cognitively impaired HIV-positive individuals. Among the HIV-positive participants, the correlation between tau PET SUVRs and both HIV loads and CD4+ T-cell counts (recent and nadir). Tau PET SUVRs were similar for HIV-positive individuals and HIV-negative control individuals. Individuals with symptomatic Alzheimer disease had elevated tau PET SUVRs. Tau PET SUVRs did not correlate with impairment or clinical markers in HIV-positive participants. Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.

Original languageEnglish
Article numberjiy663
Pages (from-to)68-72
Number of pages5
JournalJournal of Infectious Diseases
Volume220
Issue number1
DOIs
StatePublished - Jun 5 2019

Keywords

  • Alzheimer's disease
  • HIV dementia
  • positron emission tomography

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