@article{e9533d06103e4012b805945f72491b85,
title = "Tau pathology in cognitively normal older adults",
abstract = "Introduction: Tau pathology, a hallmark of Alzheimer's disease, is observed in the brains of virtually all individuals over 70 years. Methods: Using 18F-AV-1451 (18F-flortaucipir) positron emission tomography, we evaluated tau pathology in 54 cognitively normal participants (mean age: 77.5 years, SD: 8.9) from the Baltimore Longitudinal Study of Aging. We assessed associations between positron emission tomography signal and age, sex, race, and amyloid positivity. We investigated relationships between regional signal and retrospective rates of change in regional volumes and cognitive function adjusting for age, sex, and amyloid status. Results: Greater age, male sex, black race, and amyloid positivity were associated with higher 18F-AV-1451 retention in distinct brain regions. Retention in the entorhinal cortex was associated with lower entorhinal volume (β = −1.124, SE = 0.485, P =.025) and a steeper decline in memory performance (β = −0.086, SE = 0.039, P =.029). Discussion: Assessment of medial temporal tau pathology will provide insights into early structural brain changes associated with later cognitive impairment and Alzheimer's disease.",
keywords = "AV-1451, Cognition, Cognitively normal, FTP, Flortaucipir, Longitudinal, PET, T807, Tau, Volume",
author = "Jacob Ziontz and Murat Bilgel and Shafer, {Andrea T.} and Abhay Moghekar and Wendy Elkins and Jessica Helphrey and Gabriela Gomez and Danielle June and McDonald, {Michael A.} and Dannals, {Robert F.} and Azad, {Babak Behnam} and Luigi Ferrucci and Wong, {Dean F.} and Resnick, {Susan M.}",
note = "Funding Information: A.M. has a research grant funded by Fujirebio Diagnostics Ltd. D.F.W. receives funding from Lundbeck, Five Eleven Pharma, Hoffman La Roche (Roche Neuroscience), Janssen, AVID Pharma (Lilly), Cerveau, and NIH.The authors thank the Baltimore Longitudinal Study of Aging participants and staff; the Laboratory of Behavioral Neuroscience Neuropsychology Testing Group; Noble George, Daniel Holt, Hong Fan, and the rest of the Johns Hopkins PET facility staff for their dedication to the BLSA studies and their assistance, and the Center for Biomedical Image Computing and Analytics for providing MUSE labels and their contributions to MRI analysis. The authors received valuable feedback from their colleagues at the National Institute on Aging, in particular from Dr. Lori Beason-Held on neuroanatomy, for which they are grateful. They also thank Avid Radiopharmaceuticals for enabling the use of the 18F-AV-1451 tracer and providing the precursor. Avid Radiopharmaceuticals did not provide direct funding for any of the PET studies nor personnel and were not involved in data analysis or interpretation. This research was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. Funding Information: This research was supported by the Intramural Research Program of the National Institute on Aging , National Institutes of Health . Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = dec,
doi = "10.1016/j.dadm.2019.07.007",
language = "English",
volume = "11",
pages = "637--645",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
}