@article{6a7a0aba9d48470ca55e79de9c2e64a0,
title = "Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance among Older Adults with and without Preclinical Alzheimer's Disease",
abstract = "Abnormal levels of Alzheimer's disease (AD) biomarkers, measured by positron emission tomography imaging using amyloid-based radiotracers and cerebrospinal fluid, are associated with impaired driving performance in older adults. We examined whether preclinical AD staging, defined using amyloid imaging and tau imaging using the radiotracer T807 (AKA flortaucipir or AV-1451), was associated with receiving a marginal/fail rating on a standardized road test (n-=-42). Participants at Stage 2 (positive amyloid and tau scans) of preclinical AD were more likely to receive a marginal/fail rating compared to participants at Stage 0 or 1. Stage 2 preclinical AD may manifest in worse driving performance.",
keywords = "Alzheimer's disease, amyloid, driving performance, imaging, noncognitive outcomes, tau",
author = "Roe, {Catherine M.} and Babulal, {Ganesh M.} and Shruti Mishra and Gordon, {Brian A.} and Stout, {Sarah H.} and Ott, {Brian R.} and Carr, {David B.} and Ances, {Beau M.} and Morris, {John C.} and Benzinger, {Tammie L.S.}",
note = "Funding Information: Funding for this study was provided by the National Institute on Aging [R01-AG056466, R01-AG043434, R01AG43434-03S1, P50-AG05681, P01-AG03991, P01-AG026276, UL1TR000448, 1P30NS098577, EB009352]; the Alzheimer{\textquoteright}s Association [AARFD-16-439140]; the Charles and Joanne Knight Alzheimer{\textquoteright}s Research Initiative of the Washington University Knight Alzheimer{\textquoteright}s Disease Research Center (ADRC), the David and Betty Farrell Medical Research Fund, the Daniel J Brennan Alzheimer Research Fund, the Thomas E. Brew Foundation Fund, the Fred Simmons and Olga Mohan Alzheimer Research Support Fund, and by Avid Radiopharmaceuticals. The authors thank the participants, investigators, and staff of the Knight ADRC Clinical Core (participant assessments), the investigators and staff of the Driving Performance in Preclinical Alzheimer{\textquoteright}s Disease study (R01-AG043434), the investigators and staff of the Mallinckrodt Institute of Radiology. Publisher Copyright: {\textcopyright} 2018 - IOS Press and the authors. All rights reserved.",
year = "2017",
doi = "10.3233/JAD-170521",
language = "English",
volume = "61",
pages = "509--513",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
number = "2",
}