Taspase 1: A protease with many biological surprises

Hidetaka Niizuma; Emily H. Cheng; James J. Hsieh

doi:10.1080/23723556.2014.999513

Taspase 1: A protease with many biological surprises

Hidetaka Niizuma, Emily H. Cheng, James J. Hsieh

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

Original language	English
Article number	e999513
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2014.999513
State	Published - Oct 2 2015

Keywords

CDK inhibitor
MLL
TFIIA
Taspase 1
cyclin

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10.1080/23723556.2014.999513

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title = "Taspase 1: A protease with many biological surprises",

abstract = "Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.",

keywords = "CDK inhibitor, MLL, TFIIA, Taspase 1, cyclin",

author = "Hidetaka Niizuma and Cheng, {Emily H.} and Hsieh, {James J.}",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Hidetaka Niizuma, Emily H Cheng, and James J Hsieh.",

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AU - Cheng, Emily H.

AU - Hsieh, James J.

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N2 - Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

AB - Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

KW - CDK inhibitor

KW - MLL

KW - TFIIA

KW - Taspase 1

KW - cyclin

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Taspase 1: A protease with many biological surprises

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Keywords

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