TY - JOUR
T1 - Tarsal and metatarsal bone mineral density measurement using volumetric quantitative computed tomography
AU - Commean, Paul K.
AU - Ju, Tao
AU - Liu, Lu
AU - Sinacore, David R.
AU - Hastings, Mary K.
AU - Mueller, Michael J.
N1 - Funding Information:
This study was supported by the National Center for Medical Rehabilitation Research and National Institute of Diabetes and Digestive and Kidney Diseases and the National Institutes of Health Grants.
Funding Information:
We would like to thank Dr. Fred W. Prior for his collaborative support of this project. We would also like to thank Ryan Goldberg for his repeated measurements of the eight subjects with diabetes and peripheral neuropathy. Funding was provided by the National Institutes of Health, National Center of Medical Rehabilitation and Research (RO1 HD36895) and National Institute of Diabetes and Digestive and Kidney Diseases (R21 DK079457). The authors acknowledge the Prevention and Control Research Core of the Washington University Diabetes Research and Training Center (P60 DK20579) for their assistance in subject recruitment. We thank Richard Robb and his associates of the Mayo Biomedical Imaging Resource, Rochester, MN, for providing the Analyze software.
PY - 2009/10
Y1 - 2009/10
N2 - A new method for measuring bone mineral density (BMD) of the tarsal and metatarsals is described using volumetric quantitative computed tomography (VQCT) in subjects with diabetes mellitus and peripheral neuropathy. VQCT images of a single foot were acquired twice from eight subjects (mean age 51 [11 SD], seven males, one female). The cortical shells of the seven tarsal and five metatarsal bones were identified and semiautomatically segmented from adjacent bones. Volume and BMD of each bone were measured separately from the two acquired scans for each subject. Whole-bone semiautomatic segmentation measurement errors were determined as the root mean square coefficient of variation for the volume and BMD of 0.8% and 0.9%, respectively. In addition to the whole-bone segmentation methods, we performed atlas-based partitioning of subregions within the second metatarsal for all subjects, from which the volumes and BMDs were obtained for each subregion. The subregion measurement BMD errors (root mean square coefficient of variation) within the shaft, proximal end, and distal end were shown to vary by approximately 1% between the two scans of each subject. The new methods demonstrated large variations in BMDs between the 12 bones of the foot within a subject and between subjects, and between subregions within the second metatarsal. These methods can provide an important outcome measure for clinical research trials investigating the effects of interventions, aging, or disease progression on bone loss, or gain, in individual foot bones.
AB - A new method for measuring bone mineral density (BMD) of the tarsal and metatarsals is described using volumetric quantitative computed tomography (VQCT) in subjects with diabetes mellitus and peripheral neuropathy. VQCT images of a single foot were acquired twice from eight subjects (mean age 51 [11 SD], seven males, one female). The cortical shells of the seven tarsal and five metatarsal bones were identified and semiautomatically segmented from adjacent bones. Volume and BMD of each bone were measured separately from the two acquired scans for each subject. Whole-bone semiautomatic segmentation measurement errors were determined as the root mean square coefficient of variation for the volume and BMD of 0.8% and 0.9%, respectively. In addition to the whole-bone segmentation methods, we performed atlas-based partitioning of subregions within the second metatarsal for all subjects, from which the volumes and BMDs were obtained for each subregion. The subregion measurement BMD errors (root mean square coefficient of variation) within the shaft, proximal end, and distal end were shown to vary by approximately 1% between the two scans of each subject. The new methods demonstrated large variations in BMDs between the 12 bones of the foot within a subject and between subjects, and between subregions within the second metatarsal. These methods can provide an important outcome measure for clinical research trials investigating the effects of interventions, aging, or disease progression on bone loss, or gain, in individual foot bones.
KW - Bone mineral density
KW - Diabetes mellitus
KW - Foot
KW - Peripheral neuropathy
KW - QCT
UR - http://www.scopus.com/inward/record.url?scp=70349266853&partnerID=8YFLogxK
U2 - 10.1007/s10278-008-9118-z
DO - 10.1007/s10278-008-9118-z
M3 - Article
C2 - 18478296
AN - SCOPUS:70349266853
SN - 0897-1889
VL - 22
SP - 492
EP - 502
JO - Journal of Digital Imaging
JF - Journal of Digital Imaging
IS - 5
ER -