Targeting tumor-infiltrating macrophages to combat cancer

Roheena Z. Panni, David C. Linehan, David G. Denardo

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations

Abstract

Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence that macrophages promote cancer initiation and malignant progression. Therefore, these cells represent potential targets for therapeutic benefit. In this review, we will summarize macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipulation of specific macrophage populations can be used for therapeutic purposes through translational approaches.

Original languageEnglish
Pages (from-to)1075-1087
Number of pages13
JournalImmunotherapy
Volume5
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • CCR2
  • CSF1R
  • cancer
  • macrophage
  • therapeutic

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