Targeting the Microenvironment in Acute Myeloid Leukemia

Armin Rashidi, Geoffrey L. Uy

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

The bone marrow microenvironment plays a critical role in the development, progression, and relapse of acute myeloid leukemia (AML). Similar to normal hematopoietic stem cells, AML blasts express receptors on their surface, allowing them to interact with specific components of the marrow microenvironment. These interactions contribute to both chemotherapy resistance and disease relapse. Preclinical studies and early phase clinical trials have demonstrated the potential for targeting the tumor-microenvironment interactions in AML. Agents currently under investigation include hypoxia-inducible agents and inhibitors of CXCR4 and adhesion molecules such as VLA-4 and E-selectin.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalCurrent Hematologic Malignancy Reports
Volume10
Issue number2
DOIs
StatePublished - Jun 28 2015

Keywords

  • Leukemia
  • Mesenchymal
  • Microenvironment
  • Niche
  • Resistance
  • Stem cells

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