Targeting the expression of integrin receptors in tumors

S. Bloch; K. Liang; R. B. Dorshow; Y. Ye; S. Achilefu

doi:10.1117/12.533160

Targeting the expression of integrin receptors in tumors

S. Bloch, K. Liang, R. B. Dorshow, Y. Ye, S. Achilefu

Research output: Contribution to journal › Conference article › peer-review

5 Scopus citations

Abstract

Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Additionally, αvβ3 integrin expression has been linked to tumor metastasis and targeting this cell surface protein could provide a viable approach to image and evaluate the metastatic potential of tumors. Accordingly, we evaluated the selective retention of some near infrared (NIR) fluorescent probes in nude mice bearing A549 lung cancer xenograft that express αvβ3 integrin. Our preliminary results indicate that a novel NIR probe designed to target this integrin selectively accumulated in A549 tumor while other non-integrin specific probes were not retained in the tumor. Blocking studies show that tumor uptake of the probe is mediated by αvβ3 integrin receptor.

Original language	English
Pages (from-to)	222-228
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5329
DOIs	https://doi.org/10.1117/12.533160
State	Published - 2004
Event	Genetically Engineered and Optical Probes for Biomedical Applications II - San Jose, CA, United States Duration: Jan 24 2004 → Jan 27 2004

Keywords

Cell surface receptors
Integrin
Mouse
Optical imaging
Peptide
Tumor

Access to Document

10.1117/12.533160

Cite this

@article{bcc25ed3b7904e8eb8048a18e234f5f6,

title = "Targeting the expression of integrin receptors in tumors",

abstract = "Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Additionally, αvβ3 integrin expression has been linked to tumor metastasis and targeting this cell surface protein could provide a viable approach to image and evaluate the metastatic potential of tumors. Accordingly, we evaluated the selective retention of some near infrared (NIR) fluorescent probes in nude mice bearing A549 lung cancer xenograft that express αvβ3 integrin. Our preliminary results indicate that a novel NIR probe designed to target this integrin selectively accumulated in A549 tumor while other non-integrin specific probes were not retained in the tumor. Blocking studies show that tumor uptake of the probe is mediated by αvβ3 integrin receptor.",

keywords = "Cell surface receptors, Integrin, Mouse, Optical imaging, Peptide, Tumor",

author = "S. Bloch and K. Liang and Dorshow, {R. B.} and Y. Ye and S. Achilefu",

year = "2004",

doi = "10.1117/12.533160",

language = "English",

volume = "5329",

pages = "222--228",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

note = "Genetically Engineered and Optical Probes for Biomedical Applications II ; Conference date: 24-01-2004 Through 27-01-2004",

}

TY - JOUR

T1 - Targeting the expression of integrin receptors in tumors

AU - Bloch, S.

AU - Liang, K.

AU - Dorshow, R. B.

AU - Ye, Y.

AU - Achilefu, S.

PY - 2004

Y1 - 2004

N2 - Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Additionally, αvβ3 integrin expression has been linked to tumor metastasis and targeting this cell surface protein could provide a viable approach to image and evaluate the metastatic potential of tumors. Accordingly, we evaluated the selective retention of some near infrared (NIR) fluorescent probes in nude mice bearing A549 lung cancer xenograft that express αvβ3 integrin. Our preliminary results indicate that a novel NIR probe designed to target this integrin selectively accumulated in A549 tumor while other non-integrin specific probes were not retained in the tumor. Blocking studies show that tumor uptake of the probe is mediated by αvβ3 integrin receptor.

AB - Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Additionally, αvβ3 integrin expression has been linked to tumor metastasis and targeting this cell surface protein could provide a viable approach to image and evaluate the metastatic potential of tumors. Accordingly, we evaluated the selective retention of some near infrared (NIR) fluorescent probes in nude mice bearing A549 lung cancer xenograft that express αvβ3 integrin. Our preliminary results indicate that a novel NIR probe designed to target this integrin selectively accumulated in A549 tumor while other non-integrin specific probes were not retained in the tumor. Blocking studies show that tumor uptake of the probe is mediated by αvβ3 integrin receptor.

KW - Cell surface receptors

KW - Integrin

KW - Mouse

KW - Optical imaging

KW - Peptide

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=7644231265&partnerID=8YFLogxK

U2 - 10.1117/12.533160

DO - 10.1117/12.533160

M3 - Conference article

AN - SCOPUS:7644231265

SN - 0277-786X

VL - 5329

SP - 222

EP - 228

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Genetically Engineered and Optical Probes for Biomedical Applications II

Y2 - 24 January 2004 through 27 January 2004

ER -

Targeting the expression of integrin receptors in tumors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this