Targeting the bone marrow in waldenstrom macroglobulinemia

Irene M. Ghobrial, Zhang Yong, Liu Yang, Ngo Hai, Feda Azab, Antonio Sacco, Abdelkareem Azab, Patricia Maiso, Brittany Morgan, Phong Quang, Ghayas C. Issa, Xavier Leleu, Aldo M. Roccaro

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4 Scopus citations

Abstract

Waldenstrom macroglobulinemia (WM) is a low-grade B-cell lymphoma characterized by widespread involvement of the bone marrow with lymphoplasmacytic cells. In approximately 20% of patients, the malignant clone also involves the lymph nodes and induces hepatosplenomegaly. The mechanisms by which the tumor cells home to the bone marrow and preferentially reside in the marrow niches are not fully elucidated. In this review, we examine the role of the bone marrow microenvironment in the regulation of cell growth, survival and cell dissemination in WM. We also summarize specific regulators of niche-dependent tumor proliferation in WM. These include chemokines, adhesion molecules, Src/PI3K/Akt/mTOR signaling, NF-kB activation, and micro-RNA regulation in WM. Targeting these pathways in clinical trials could lead to significant responses in this rare disease.

Original languageEnglish
Pages (from-to)S65-S69
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue numberSUPPL.1
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Adhesion
  • Bone marrow
  • Cell trafficking
  • Homing
  • Niche
  • Waldenstrom

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    Ghobrial, I. M., Yong, Z., Yang, L., Hai, N., Azab, F., Sacco, A., Azab, A., Maiso, P., Morgan, B., Quang, P., Issa, G. C., Leleu, X., & Roccaro, A. M. (2011). Targeting the bone marrow in waldenstrom macroglobulinemia. Clinical Lymphoma, Myeloma and Leukemia, 11(SUPPL.1), S65-S69. https://doi.org/10.1016/j.clml.2011.03.022