Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Maud Gratuze; David M. Holtzman

doi:10.1016/j.neuron.2021.02.014

Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Maud Gratuze
, David M. Holtzman

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

Original language	English
Pages (from-to)	741-743
Number of pages	3
Journal	Neuron
Volume	109
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2021.02.014
State	Published - Mar 3 2021

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title = "Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits",

abstract = "Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.",

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AU - Holtzman, David M.

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N2 - Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

AB - Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

UR - https://www.scopus.com/pages/publications/85102542508

U2 - 10.1016/j.neuron.2021.02.014

DO - 10.1016/j.neuron.2021.02.014

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SP - 741

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JO - Neuron

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IS - 5

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Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Abstract

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