Targeting pain-evoking transient receptor potential channels for the treatment of pain

Jialie Luo, Edgar T. Walters, Susan M. Carlton, Hongzhen Hu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.

Original languageEnglish
Pages (from-to)652-663
Number of pages12
JournalCurrent Neuropharmacology
Volume11
Issue number6
DOIs
StatePublished - 2013

Keywords

  • Drug target
  • Inflammation
  • Neuropathy
  • Pain
  • Pain management
  • Transient receptor potential channels

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