Abstract
The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer. We recently described the metabolic adaptations that occur upon PHGDH inhibition in osteosarcoma. PHGDH inhibition causes metabolite accumulation that activates the mechanistic target of rapamycin (mTOR) signaling, sensitizing osteosarcoma to non-rapalog mTOR inhibition.
Original language | English |
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Article number | 1902250 |
Journal | Molecular and Cellular Oncology |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
Keywords
- PHGDH
- mTORC1
- methotrexate
- osteosarcoma
- perhexiline
- serine