Targeting of proteins into the eukaryotic secretory pathway: Signal peptide structure/function relationships

Steven F. Nothwehr, Jeffrey I. Gordon

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Much progress has been made in recent years regarding the mechanisms of targeting of secretory proteins to, and across, the endoplasmic reticulum (ER) membrane. Many of the cellular components involved in mediating translocation across this bilayer have been identified and characterized. Polypeptide domains of secretory proteins, termed signal peptides, have been shown to be necessary, and in most cases sufficient, for entry of preproteins into the lumen of the ER. These NH2‐ terminal segments appear to serve multiple roles in targeting and translocation. The structural features which mediate their multiple functions are currently the subject of intense study.

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalBioEssays
Volume12
Issue number10
DOIs
StatePublished - Oct 1990

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