Targeting monocyte recruitment in CNS autoimmune disease

Leonid Izikson, Robyn S. Klein, Andrew D. Luster, Howard L. Weiner

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases. Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS). Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalClinical Immunology
Volume103
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • CCR2
  • Chemotaxis
  • EAE
  • MCP-1
  • MS
  • Monocyte
  • Treatment

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