Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno; Eynav Klechevsky; Nathalie Schmitt; Ling Ni; Anne Laure Flamar; Sandra Zurawski; Gerard Zurawski; Karolina Palucka; Jacques Banchereau; Sang Kon Oh

doi:10.1016/j.smim.2011.01.004

Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno, Eynav Klechevsky, Nathalie Schmitt, Ling Ni, Anne Laure Flamar, Sandra Zurawski, Gerard Zurawski, Karolina Palucka, Jacques Banchereau, Sang Kon Oh

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Seminars in immunology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2011.01.004
State	Published - Feb 2011

Keywords

Antibody responses
Cytotoxic T lymphocyte responses
DC targeting
Dendritic cell subsets
Human
Vaccines

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10.1016/j.smim.2011.01.004

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title = "Targeting human dendritic cell subsets for improved vaccines",

abstract = "Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.",

keywords = "Antibody responses, Cytotoxic T lymphocyte responses, DC targeting, Dendritic cell subsets, Human, Vaccines",

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AU - Ueno, Hideki

AU - Klechevsky, Eynav

AU - Schmitt, Nathalie

AU - Ni, Ling

AU - Flamar, Anne Laure

AU - Zurawski, Sandra

AU - Zurawski, Gerard

AU - Palucka, Karolina

AU - Banchereau, Jacques

AU - Oh, Sang Kon

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AB - Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

KW - Antibody responses

KW - Cytotoxic T lymphocyte responses

KW - DC targeting

KW - Dendritic cell subsets

KW - Human

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Targeting human dendritic cell subsets for improved vaccines

Abstract

Keywords

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