Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno, Eynav Klechevsky, Nathalie Schmitt, Ling Ni, Anne Laure Flamar, Sandra Zurawski, Gerard Zurawski, Karolina Palucka, Jacques Banchereau, Sang Kon Oh

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalSeminars in immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Keywords

  • Antibody responses
  • Cytotoxic T lymphocyte responses
  • DC targeting
  • Dendritic cell subsets
  • Human
  • Vaccines

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    Ueno, H., Klechevsky, E., Schmitt, N., Ni, L., Flamar, A. L., Zurawski, S., Zurawski, G., Palucka, K., Banchereau, J., & Oh, S. K. (2011). Targeting human dendritic cell subsets for improved vaccines. Seminars in immunology, 23(1), 21-27. https://doi.org/10.1016/j.smim.2011.01.004