Targeting brain tumor cAMP: The case for sex-specific therapeutics

Nicole M. Warrington, Tao Sun, Joshua B. Rubin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A relationship between cyclic adenosine 3', 5'-monophosphate (cAMP) levels and brain tumor biology has been evident for nearly as long as cAMP and its synthetase, adenylate cyclase (ADCY) have been known. The importance of the pathway in brain tumorigenesis has been demonstrated in vitro and in multiple animal models. Recently, we provided human validation for a cooperating oncogenic role for cAMP in brain tumorigenesis when we found that SNPs in ADCY8 were correlated with glioma (brain tumor) risk in individuals with Neurofibromatosis type 1 (NF1). Together, these studies provide a strong rationale for targeting cAMP in brain tumor therapy. However, the cAMP pathway is well-known to be sexually dimorphic, and SNPs in ADCY8 affected glioma risk in a sex-specific fashion, elevating the risk for females while protecting males. The cAMP pathway can be targeted at multiple levels in the regulation of its synthesis and degradation. Sex differences in response to drugs that target cAMP regulators indicate that successful targeting of the cAMP pathway for brain tumor patients is likely to require matching specific mechanisms of drug action with patient sex.

Original languageEnglish
Article number153
JournalFrontiers in Pharmacology
Issue numberJUL
StatePublished - 2015


  • Brain tumors
  • CAMP
  • PDE
  • Primary cilia
  • Sex differences


Dive into the research topics of 'Targeting brain tumor cAMP: The case for sex-specific therapeutics'. Together they form a unique fingerprint.

Cite this