Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis

Martina Molgora; Marco Colonna

doi:10.1016/j.ccell.2025.02.020

Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis

Martina Molgora
, Marco Colonna

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Melanoma brain metastasis (MBM) is associated with poor prognosis. In this issue of Cancer Cell, Rodriguez-Baena et al. identify nuclear factor κB (NF-κB) (Rela) as a driver of pro-tumoral microglia in MBM. While Rela deletion reprograms microglia, enhancing proinflammatory and anti-metastasis T cell responses, RELA activation in human macrophages correlates with immunotherapy resistance.

Original language	English
Pages (from-to)	328-329
Number of pages	2
Journal	Cancer Cell
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.ccell.2025.02.020
State	Published - Mar 10 2025

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10.1016/j.ccell.2025.02.020

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title = "Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis",

abstract = "Melanoma brain metastasis (MBM) is associated with poor prognosis. In this issue of Cancer Cell, Rodriguez-Baena et al. identify nuclear factor κB (NF-κB) (Rela) as a driver of pro-tumoral microglia in MBM. While Rela deletion reprograms microglia, enhancing proinflammatory and anti-metastasis T cell responses, RELA activation in human macrophages correlates with immunotherapy resistance.",

author = "Martina Molgora and Marco Colonna",

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T2 - NF-κB as a therapeutic gateway in melanoma brain metastasis

AU - Molgora, Martina

AU - Colonna, Marco

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Y1 - 2025/3/10

N2 - Melanoma brain metastasis (MBM) is associated with poor prognosis. In this issue of Cancer Cell, Rodriguez-Baena et al. identify nuclear factor κB (NF-κB) (Rela) as a driver of pro-tumoral microglia in MBM. While Rela deletion reprograms microglia, enhancing proinflammatory and anti-metastasis T cell responses, RELA activation in human macrophages correlates with immunotherapy resistance.

AB - Melanoma brain metastasis (MBM) is associated with poor prognosis. In this issue of Cancer Cell, Rodriguez-Baena et al. identify nuclear factor κB (NF-κB) (Rela) as a driver of pro-tumoral microglia in MBM. While Rela deletion reprograms microglia, enhancing proinflammatory and anti-metastasis T cell responses, RELA activation in human macrophages correlates with immunotherapy resistance.

UR - https://www.scopus.com/pages/publications/85219565269

U2 - 10.1016/j.ccell.2025.02.020

DO - 10.1016/j.ccell.2025.02.020

M3 - Comment/debate

C2 - 40068588

AN - SCOPUS:85219565269

SN - 1535-6108

VL - 43

SP - 328

EP - 329

JO - Cancer Cell

JF - Cancer Cell

IS - 3

ER -

Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis

Abstract

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