Targeting apolipoprotein E for treating Alzheimer's disease

Kelly R. Bales, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The ε4 allele of the apolipoprotein E gene represents the most widely reproduced and robust susceptibility loci for the most common late onset and sporadic forms of Alzheimer's disease. While the discovery of this now widely replicated association was reported more than 25 years ago, few therapeutic interventions that specifically target the apolipoprotein pathway in brain have emerged. Here we discuss our current understanding of apolipoprotein E biology in brain, its relationship to the pathogenesis of Alzheimer's disease and present potential future avenues for exploration that may be amenable to drug development.

Original languageEnglish
Article number134366
JournalNeuroscience Letters
Volume709
DOIs
StatePublished - Sep 14 2019

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Beta-amyloid
  • Neurodegeneration
  • Tau

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