TY - JOUR
T1 - Targeted ultrasonic contrast agents for molecular imaging and therapy
AU - Lanza, Gregory M.
AU - Wickline, Samuel A.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Targeted contrast agents are expanding the detectability and diagnosis of pathology from a strict anatomic to biochemical basis. Moreover, these new agents, in their various forms, offer the potential for site-specific drug and gene delivery, ie, the "magic bullet" first postulated by Paul Erhlich 100 years ago. The ability to direct drugs to the molecular signatures of disease, to confirm noninvasively their presence at the site-of-interest, and to quantify the adequacy of local drug concentration at the time of treatment, ie, rational targeted drug delivery, offers exciting new clinical paradigms in the near future.
AB - Targeted contrast agents are expanding the detectability and diagnosis of pathology from a strict anatomic to biochemical basis. Moreover, these new agents, in their various forms, offer the potential for site-specific drug and gene delivery, ie, the "magic bullet" first postulated by Paul Erhlich 100 years ago. The ability to direct drugs to the molecular signatures of disease, to confirm noninvasively their presence at the site-of-interest, and to quantify the adequacy of local drug concentration at the time of treatment, ie, rational targeted drug delivery, offers exciting new clinical paradigms in the near future.
UR - http://www.scopus.com/inward/record.url?scp=0034860985&partnerID=8YFLogxK
U2 - 10.1053/pcad.2001.26440
DO - 10.1053/pcad.2001.26440
M3 - Article
C2 - 11533924
AN - SCOPUS:0034860985
SN - 0033-0620
VL - 44
SP - 13
EP - 31
JO - Progress in cardiovascular diseases
JF - Progress in cardiovascular diseases
IS - 1
ER -