TY - JOUR
T1 - Targeted ultrasonic contrast agents for molecular imaging and therapy.
AU - Lanza, Gregory M.
AU - Wickline, Samuel A.
PY - 2003/12
Y1 - 2003/12
N2 - Targeted contrast agents are expanding the detectability and diagnosis of pathology from a strict anatomic to biochemical basis. Moreover, these new agents, in their various forms, offer the potential for site-specific drug and gene delivery, i.e., the "magic bullet" first postulated by Paul Erhlich 100 years ago. The ability to direct drugs to the molecular signatures of disease, to confirm noninvasively their presence at the site-of-interest, and to quantify the adequacy of local drug concentration at the time of treatment, ie, rational targeted drug delivery, offers exciting new clinical paradigms in the near future.
AB - Targeted contrast agents are expanding the detectability and diagnosis of pathology from a strict anatomic to biochemical basis. Moreover, these new agents, in their various forms, offer the potential for site-specific drug and gene delivery, i.e., the "magic bullet" first postulated by Paul Erhlich 100 years ago. The ability to direct drugs to the molecular signatures of disease, to confirm noninvasively their presence at the site-of-interest, and to quantify the adequacy of local drug concentration at the time of treatment, ie, rational targeted drug delivery, offers exciting new clinical paradigms in the near future.
UR - http://www.scopus.com/inward/record.url?scp=2342513540&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2003.11.001
DO - 10.1016/j.cpcardiol.2003.11.001
M3 - Article
C2 - 14691443
AN - SCOPUS:2342513540
SN - 0146-2806
VL - 28
SP - 625
EP - 653
JO - Current problems in cardiology
JF - Current problems in cardiology
IS - 12
ER -