Abstract
Five peptides binding to somatostatin and bombesin receptors were conjugated to 4-azido-2,3,5,6-tetrafluorophenylbenzoic acid, a Type 1 photosensitizer, at the N-terminal position. The receptor affinities were determined by competition binding assay using two different pancreatic tumor cell lines, CA20948 and AR42-J, that express somatostatin-2 (SST-2) and bombesin receptors respectively All compounds exhibited high receptor specificity, i.e., the IC50 values ranged between 1.0 to 64.0 nM. These conjugates may be useful for targeted Type 1 phototherapy via the generation of nitrenes at the cell surfaces expressing these receptors.
Original language | English |
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Pages (from-to) | 129-132 |
Number of pages | 4 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 4259 |
DOIs | |
State | Published - 2001 |
Event | Biomarkers and Biological Spectral Imaging - San Jose, CA, United States Duration: Jan 23 2001 → … |