Targeted tumor killing via an intracellular antibody against erbB-2

Jessy Deshane, Gene P. Siegal, Ronald D. Alvarez, Ming H. Wang, Meizhen Feng, Gustavo Cabrera, Tiepu Liu, Mark Kay, David T. Curiel

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Specific killing of erbB-2-overexpressing tumor cells can be achieved using expression of an intracellular antibody directed against the erbB-2 oncoprotein. We have developed a strategy using a recombinant adenovirus encoding an anti-erbB-2 single chain antibody to achieve targeted tumor cell killing in vivo and can show significantly prolonged survival of animals carrying a human ovarian carcinoma tumor burden within their peritoneal cavities. This strategy of gene therapy for ovarian carcinoma offers the potential to achieve highly specific, targeted killing of human tumor cells and thus establishes the rationale to undertake human clinical trials on this basis.

Original languageEnglish
Pages (from-to)2980-2989
Number of pages10
JournalJournal of Clinical Investigation
Volume96
Issue number6
DOIs
StatePublished - Dec 1995

Keywords

  • antibody
  • erbB-2
  • gene therapy
  • ovarian carcinoma
  • sFv

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