Targeted Therapy in Solid Tumors: Lung Cancer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The treatment for metastatic non-small cell lung cancer (NSCLC) has been mostly empiric, with the choice of regimens decided based on personal preferences and the toxicity profile. Recent studies have shown a significant benefit from targeted therapies in patients with molecularly selected tumors. Nevertheless, despite the unprecedented response rates and progression-free survival, essentially all patients eventually develop secondary resistance and tumor progression. Furthermore, the benefits are currently restricted to a small fraction of patients. Rationally designed trials matching genomic abnormalities with the most appropriate targeted therapies represent a significant advance in the management of NSCLC and will hopefully allow the development of more effective and less toxic treatment options. These advances in targeted therapy may ultimately lead to improved cure rates for patients with earlier stage disease and increased survival for those with incurable metastatic disease.

Original languageEnglish
Title of host publicationTargeted Therapy in Translational Cancer Research
PublisherWiley Blackwell
Number of pages7
ISBN (Electronic)9781118468678
ISBN (Print)9781118468579
StatePublished - Oct 30 2015


  • ALK
  • Adenocarcinoma
  • EGFR
  • Lung cancer
  • Lung cancer mutation consortium
  • Squamous cell carcinoma
  • Targeted therapy


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