TY - CHAP
T1 - Targeted Radiopharmaceuticals
T2 - Advances in Radiopharmacology and Radiopharmacy
AU - Cutler, Cathy S.
AU - Schwarz, Sally W.
N1 - Publisher Copyright:
© 2012 by Taylor and Francis Group, LLC.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Nuclear imaging is noninvasive and therefore unique in its ability to evaluate biological pathways and function at the molecular level without perturbing the systems under investigation. Other techniques require invasive, destructive sampling of cells and tissues that yields a nonuniform, static snapshot at a single point in time. Molecular imaging is used to elucidate basic biology, diagnose and stage disease, and evaluate the in vitro properties of proposed drugs and aid in their translation from the bench to the clinic. is requires evaluating the drugs in appropriate animal models to determine distribution, concentration, and clearance in organs and tissues over time, and this can be done most eciently and eectively by imaging. e ultimate goal is to develop a data set that can accurately predict what drug dose can be administered safely and eectively to humans.
AB - Nuclear imaging is noninvasive and therefore unique in its ability to evaluate biological pathways and function at the molecular level without perturbing the systems under investigation. Other techniques require invasive, destructive sampling of cells and tissues that yields a nonuniform, static snapshot at a single point in time. Molecular imaging is used to elucidate basic biology, diagnose and stage disease, and evaluate the in vitro properties of proposed drugs and aid in their translation from the bench to the clinic. is requires evaluating the drugs in appropriate animal models to determine distribution, concentration, and clearance in organs and tissues over time, and this can be done most eciently and eectively by imaging. e ultimate goal is to develop a data set that can accurately predict what drug dose can be administered safely and eectively to humans.
UR - http://www.scopus.com/inward/record.url?scp=85137858679&partnerID=8YFLogxK
U2 - 10.1201/b11628-14
DO - 10.1201/b11628-14
M3 - Chapter
AN - SCOPUS:85137858679
SN - 9781439841952
SP - 91
EP - 109
BT - Targeted Molecular Imaging
PB - CRC Press
ER -