Targeted mRNA Degradation in Eukaryotes

Courtney F. Jungers; Sergej Djuranovic

doi:10.1016/B978-0-12-821618-7.00187-5

Targeted mRNA Degradation in Eukaryotes

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Genetic information is transferred during transcription and translation into a protein product. Correct protein output is essential for maintaining proper cellular homeostasis; therefore, this process is highly regulated at multiple levels. mRNA levels are a major determinant of protein output, and mRNA levels can be controlled through transcription rates and targeted mRNA degradation. Historically, scientists focused on transcriptional control, however, it has become evident that mRNA translation and degradation play an equally important part in regulating proper gene expression.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	116-126
Number of pages	11
Volume	5
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00187-5
State	Published - Jan 1 2022

Keywords

Deadenylation
Decapping
Endonuclease
MiRNA
MRNA
MRNA decay
MRNA surveillance
No-Go Decay
Non-Stop Decay
Nonsense-Mediated Decay
RNA binding proteins

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10.1016/B978-0-12-821618-7.00187-5

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title = "Targeted mRNA Degradation in Eukaryotes",

abstract = "Genetic information is transferred during transcription and translation into a protein product. Correct protein output is essential for maintaining proper cellular homeostasis; therefore, this process is highly regulated at multiple levels. mRNA levels are a major determinant of protein output, and mRNA levels can be controlled through transcription rates and targeted mRNA degradation. Historically, scientists focused on transcriptional control, however, it has become evident that mRNA translation and degradation play an equally important part in regulating proper gene expression.",

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AB - Genetic information is transferred during transcription and translation into a protein product. Correct protein output is essential for maintaining proper cellular homeostasis; therefore, this process is highly regulated at multiple levels. mRNA levels are a major determinant of protein output, and mRNA levels can be controlled through transcription rates and targeted mRNA degradation. Historically, scientists focused on transcriptional control, however, it has become evident that mRNA translation and degradation play an equally important part in regulating proper gene expression.

KW - Deadenylation

KW - Decapping

KW - Endonuclease

KW - MiRNA

KW - MRNA

KW - MRNA decay

KW - MRNA surveillance

KW - No-Go Decay

KW - Non-Stop Decay

KW - Nonsense-Mediated Decay

KW - RNA binding proteins

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VL - 5

SP - 116

EP - 126

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Targeted mRNA Degradation in Eukaryotes

Abstract

Keywords

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