Genetic information is transferred during transcription and translation into a protein product. Correct protein output is essential for maintaining proper cellular homeostasis; therefore, this process is highly regulated at multiple levels. mRNA levels are a major determinant of protein output, and mRNA levels can be controlled through transcription rates and targeted mRNA degradation. Historically, scientists focused on transcriptional control, however, it has become evident that mRNA translation and degradation play an equally important part in regulating proper gene expression.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationVolume 1-6, Second Edition
Number of pages11
ISBN (Electronic)9780128216248
StatePublished - Jan 1 2022


  • Deadenylation
  • Decapping
  • Endonuclease
  • MiRNA
  • MRNA
  • MRNA decay
  • MRNA surveillance
  • No-Go Decay
  • Non-Stop Decay
  • Nonsense-Mediated Decay
  • RNA binding proteins


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