Regulation of gene expression includes a wide array of cellular mechanisms that control abundance of RNA and protein levels. Besides the well-described mechanisms of transcriptional control, cells use a variety of posttranscriptional processes to regulate the levels and activity of RNA and protein molecules through modification, stabilization, or degradation of these molecules. In particular, changes in the amounts of messenger RNAs (mRNAs) play a major role in gene expression. In this article we will focus on the mechanisms that regulate cellular abundance of mRNAs through targeted mRNA degradation.

Original languageEnglish
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
StatePublished - 2016


  • Deadenylation
  • Decapping
  • Endonuclease
  • MRNA
  • MRNA decay
  • MRNA surveillance
  • MiRNA
  • No-go decay
  • Nonsense-mediated decay
  • Nonstop-decay
  • RNA-binding proteins


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