Targeted mRNA Degradation

S. Djuranovic, H. S. Zaher

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Regulation of gene expression includes a wide array of cellular mechanisms that control abundance of RNA and protein levels. Besides the well-described mechanisms of transcriptional control, cells use a variety of posttranscriptional processes to regulate the levels and activity of RNA and protein molecules through modification, stabilization, or degradation of these molecules. In particular, changes in the amounts of messenger RNAs (mRNAs) play a major role in gene expression. In this article we will focus on the mechanisms that regulate cellular abundance of mRNAs through targeted mRNA degradation.

Original languageEnglish
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Pages317-326
Number of pages10
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2016

Keywords

  • Deadenylation
  • Decapping
  • Endonuclease
  • MRNA
  • MRNA decay
  • MRNA surveillance
  • MiRNA
  • No-go decay
  • Nonsense-mediated decay
  • Nonstop-decay
  • RNA-binding proteins

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    Djuranovic, S., & Zaher, H. S. (2016). Targeted mRNA Degradation. In Functional Cell Biology (Vol. 3, pp. 317-326). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.30043-8