TY - JOUR
T1 - Targeted magnetic resonance imaging contrast agents.
AU - Caruthers, Shelton D.
AU - Winter, Patrick M.
AU - Wickline, Samuel A.
AU - Lanza, Gregory M.
PY - 2006
Y1 - 2006
N2 - The era of personalized medicine is emerging as physicians attempt to diagnose disease in asymptomatic individuals and treat pathology early in its natural history. A novel tool in an emerging armamentarium, molecular imaging will allow noninvasive characterization and segmentation of patients for delivering custom-tailored therapy. Nanoparticulate agents, such as superparamagnetic agents, liposomes, perfluorocarbon nanoparticle emulsions, and dendrimers, are being intensively researched as formulation platforms for various targeted clinical applications. As exemplified by perfluorocarbon nanoparticles, these new agents, in combination with the rapid innovations in imaging hardware and software, will allow the emergence of new medical diagnostic and therapeutic paradigms.
AB - The era of personalized medicine is emerging as physicians attempt to diagnose disease in asymptomatic individuals and treat pathology early in its natural history. A novel tool in an emerging armamentarium, molecular imaging will allow noninvasive characterization and segmentation of patients for delivering custom-tailored therapy. Nanoparticulate agents, such as superparamagnetic agents, liposomes, perfluorocarbon nanoparticle emulsions, and dendrimers, are being intensively researched as formulation platforms for various targeted clinical applications. As exemplified by perfluorocarbon nanoparticles, these new agents, in combination with the rapid innovations in imaging hardware and software, will allow the emergence of new medical diagnostic and therapeutic paradigms.
UR - http://www.scopus.com/inward/record.url?scp=33645234887&partnerID=8YFLogxK
M3 - Review article
C2 - 16506431
AN - SCOPUS:33645234887
SN - 1543-1894
VL - 124
SP - 387
EP - 400
JO - Methods in Molecular Medicine
JF - Methods in Molecular Medicine
ER -