Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation

Keyphrases

• Costimulation 100%
• CD28 100%
• Targeted Knock-in 100%
• Essential Pathway 100%
• Phosphoinositide 3-kinase (PI3K) 60%
• T Cell Activation 40%
• Interleukin-2 40%
• Proline 40%
• Tyrosine Motif 40%
• Glycogen Synthase Kinase 3 (GSK3) 20%
• Phosphorylation 20%
• Knock-in Mouse Model 20%
• Bcl-xL 20%
• Kinase Activation 20%
• Protein Kinase 20%
• Signaling Pathway 20%
• T Cells 20%
• Cytoplasmic Tail 20%
• Severe Disease 20%
• Tyrosine Phosphorylation 20%
• Experimental Autoimmune Encephalomyelitis 20%
• Humoral Response 20%
• Disease Manifestations 20%
• Direct Activation 20%
• Protein Kinase B 20%
• Protein Kinase B/Akt 20%
• Secretion Expression 20%
• Threonine Phosphorylation 20%

Biochemistry, Genetics and Molecular Biology

• CD28 100%
• T Cell 60%
• Phosphoinositide 3-Kinase 60%
• Secretion (Process) 40%
• Tyrosine 40%
• Cell Function 40%
• Protein Kinase B 40%
• Interleukin 2 40%
• Proline 40%
• Glycogen Synthase Kinase 3 20%
• Kinase 20%
• Phosphotransferase 20%
• C-Terminus 20%
• Protein Kinase C 20%
• Tyrosine Phosphorylation 20%
• Humoral Immunity 20%
• Threonine 20%
• Protein Kinase B 20%

Neuroscience

• CD28 100%
• Phosphoinositide 3-Kinase 60%
• T Cell 60%
• Cell Function 40%
• Proline 40%
• Interleukin 2 40%
• Protein Kinase B 40%
• C-Terminus 20%
• In Vivo 20%
• Kinase 20%
• Cell Signaling 20%
• Protein Kinase C 20%
• Protein Phosphorylation 20%
• Experimental Autoimmune Encephalomyelitis 20%
• Threonine 20%
• Humoral Immunity 20%
• Glycogen Synthase Kinase 3 20%