Targeted degradation of BET proteins in triple-negative breast cancer

Keyphrases

• Triple-negative Breast Cancer 100%
• Targeted Degradation 100%
• BET Proteins 100%
• Apoptosis 60%
• Triple-negative Breast Cancer Cells 40%
• Antitumor Activity 40%
• Gene number 40%
• BETi 40%
• Tumor 20%
• Growth Inhibition 20%
• RNA-seq Analysis 20%
• Bcl-xL 20%
• Targeted Therapy 20%
• Dosing Schedule 20%
• Small Molecule Inhibitors 20%
• Human Breast Cancer 20%
• Therapeutic Strategies 20%
• Breast Cancer Treatment 20%
• Robust Growth 20%
• Myeloid Cell leukemia-1 (Mcl-1) 20%
• Nanomolar Concentrations 20%
• Functional Investigation 20%
• Downstream Effectors 20%
• Degrader 20%
• Human Triple Negative Breast Cancer 20%
• Superior Selectivity 20%
• BET Inhibitor 20%
• Inhibitor Compound 20%
• Induced Degradation 20%
• Murine Xenograft Model 20%
• Protein Degraders 20%

Biochemistry, Genetics and Molecular Biology

• Programmed Cell Death 100%
• Cancer Cell 66%
• Antineoplastic Activity 66%
• Downregulation 33%
• Small Molecule 33%
• RNA Sequencing 33%
• Growth Inhibition 33%
• MCL1 33%
• Targeted Therapy 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Triple Negative Breast Cancer 100%
• Antitumor Activity 40%
• Breast Cancer 20%
• Bromodomain Inhibitor 20%