Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach

Joseph Burclaff, Luciana H. Osaki, Dengqun Liu, James R. Goldenring, Jason C. Mills

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even after previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone therefore is not sufficient to induce metaplasia: completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death.

Original languageEnglish
Pages (from-to)762-766.e7
JournalGastroenterology
Volume152
Issue number4
DOIs
StatePublished - Mar 1 2017

Keywords

  • Atp4b-Cre
  • CD44 Variant 9
  • Organoids
  • SPEM

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