TY - JOUR
T1 - Targeted anticytokine therapy and the failing heart
AU - Mann, Douglas L.
N1 - Funding Information:
This work was supported, in part, by research funds from the Department of Veterans Affairs and the by Grant Nos. P50 HL-O6H and RO1 HL58081-01, RO1 HL61543-01, and HL-42250-10/10 from the National Institutes of Health.
PY - 2005/6/6
Y1 - 2005/6/6
N2 - Recent studies have identified the importance of proinflammatory mediators in the development and progression of chronic heart failure (CHF). The growing appreciation of the pathophysiologic consequences of sustained expression of proinflammatory mediators in preclinical and clinical CHF models culminated in a series of multicenter clinical trials that used targeted approaches to neutralize tumor necrosis factor in patients with moderate-to-advanced CHF. However, these targeted approaches have resulted in worsening CHF, thereby raising a number of important questions about what role, if any, proinflammatory cytokines play in the pathogenesis of CHF. This review summarizes what has been learned from the negative clinical trials, as well as the potential direction of future research in this area.
AB - Recent studies have identified the importance of proinflammatory mediators in the development and progression of chronic heart failure (CHF). The growing appreciation of the pathophysiologic consequences of sustained expression of proinflammatory mediators in preclinical and clinical CHF models culminated in a series of multicenter clinical trials that used targeted approaches to neutralize tumor necrosis factor in patients with moderate-to-advanced CHF. However, these targeted approaches have resulted in worsening CHF, thereby raising a number of important questions about what role, if any, proinflammatory cytokines play in the pathogenesis of CHF. This review summarizes what has been learned from the negative clinical trials, as well as the potential direction of future research in this area.
UR - http://www.scopus.com/inward/record.url?scp=19944386296&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2005.03.007
DO - 10.1016/j.amjcard.2005.03.007
M3 - Article
C2 - 15925559
AN - SCOPUS:19944386296
SN - 0002-9149
VL - 95
SP - 9
EP - 16
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 11 SUPPL. 1
ER -