Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles

Alexandra Rodzinski, Rakesh Guduru, Ping Liang, Ali Hadjikhani, Tiffanie Stewart, Emmanuel Stimphil, Carolyn Runowicz, Richard Cote, Norman Altman, Ram Datar, Sakhrat Khizroev

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107 Scopus citations

Abstract

It is a challenge to eradicate tumor cells while sparing normal cells. We used magnetoelectric nanoparticles (MENs) to control drug delivery and release. The physics is due to electric-field interactions (i) between MENs and a drug and (ii) between drug-loaded MENs and cells. MENs distinguish cancer cells from normal cells through the membrane's electric properties; cancer cells have a significantly smaller threshold field to induce electroporation. In vitro and in vivo studies (nude mice with SKOV-3 xenografts) showed that (i) drug (paclitaxel (PTX)) could be attached to MENs (30-nm CoFe2O4 @BaTiO3 nanostructures) through surface functionalization to avoid its premature release, (ii) drug-loaded MENs could be delivered into cancer cells via application of a d.c. field (∼100 Oe), and (iii) the drug could be released off MENs on demand via application of an a.c. field (∼50 Oe, 100 Hz). The cell lysate content was measured with scanning probe microscopy and spectrophotometry. MENs and control ferromagnetic and polymer nanoparticles conjugated with HER2-neu antibodies, all loaded with PTX were weekly administrated intravenously. Only the mice treated with PTX-loaded MENs (15/200 μg) in a field for three months were completely cured, as confirmed through infrared imaging and post-euthanasia histology studies via energy-dispersive spectroscopy and immunohistochemistry.

Original languageEnglish
Article number20867
JournalScientific reports
Volume6
DOIs
StatePublished - Feb 15 2016
Externally publishedYes

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    Rodzinski, A., Guduru, R., Liang, P., Hadjikhani, A., Stewart, T., Stimphil, E., Runowicz, C., Cote, R., Altman, N., Datar, R., & Khizroev, S. (2016). Targeted and controlled anticancer drug delivery and release with magnetoelectric nanoparticles. Scientific reports, 6, [20867]. https://doi.org/10.1038/srep20867