TY - JOUR
T1 - Tangles and plaques in healthy aging and Alzheimer's disease
T2 - Independence or interaction
AU - Price, Joseph L.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Although amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD), they also occur in healthy, nondemented aging. Tangles are present in all brains over the age of 55, concentrated in specific structures around the hippocampus. The number of tangles increases with age, and with dementia severity in AD, but their relative distribution remains the same. Plaques are not ubiquitous in nondemented cases, but are prominent in all demented cares. While the incidence of plaques increases with age, their density is not related to age or dementia severity. Unlike tangles, plaques develop in the neocortex, with fewer in the hippo-campus. The differential distribution of plaques and tangles indicates independent initial formation during non-demented aging. In AD amyloid may accelerate tangle formation.
AB - Although amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD), they also occur in healthy, nondemented aging. Tangles are present in all brains over the age of 55, concentrated in specific structures around the hippocampus. The number of tangles increases with age, and with dementia severity in AD, but their relative distribution remains the same. Plaques are not ubiquitous in nondemented cases, but are prominent in all demented cares. While the incidence of plaques increases with age, their density is not related to age or dementia severity. Unlike tangles, plaques develop in the neocortex, with fewer in the hippo-campus. The differential distribution of plaques and tangles indicates independent initial formation during non-demented aging. In AD amyloid may accelerate tangle formation.
KW - Aging
KW - Alzheimer's disease
KW - Amyloid plaques
KW - Dementia
KW - Neurofibrillary tangles
UR - http://www.scopus.com/inward/record.url?scp=0028639536&partnerID=8YFLogxK
U2 - 10.1006/smns.1994.1051
DO - 10.1006/smns.1994.1051
M3 - Article
AN - SCOPUS:0028639536
SN - 1044-5765
VL - 6
SP - 395
EP - 402
JO - Seminars in the Neurosciences
JF - Seminars in the Neurosciences
IS - 6
ER -